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Real-world treatment patterns and survival outcomes for patients with stage III non-small cell lung cancer in Spain : a nationwide cohort study

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Real-world treatment patterns and survival outcomes for patients with stage III non-small cell lung cancer in Spain : a nationwide cohort study

dc.contributor.author	Provencio Pulla, Mariano
dc.contributor.author	Carcereny, Enric
dc.contributor.author	López Castro, Rafael
dc.contributor.author	Calvo, Virginia
dc.contributor.author	Rodríguez Abreu, Delvys
dc.contributor.author	Cobo, Manuel
dc.contributor.author	Ortega, Ana Laura
dc.contributor.author	Bernabé, Reyes
dc.contributor.author	Guirado, Maria
dc.contributor.author	Massuti Sureda, Bartomeu
dc.contributor.author	Barco, Edel
dc.contributor.author	Bosch Barrera, Joaquim
dc.contributor.author	Camps Herrero, Carlos
dc.contributor.author	Carroll, Robert
dc.contributor.author	Rault, Caroline
dc.contributor.author	Chaib, Carlos
dc.contributor.author	Penrod, John
dc.contributor.author	Vo, Lien
dc.contributor.author	Ralphs, Eleanor
dc.contributor.author	Daumont, Melinda
dc.date.accessioned	2023-11-06T15:07:16Z
dc.date.available	2023-11-06T15:07:16Z
dc.date.issued	2023
dc.identifier.uri	https://hdl.handle.net/10550/90967
dc.description.abstract	Background: The burden of non-small cell lung cancer (NSCLC) remains high in Spain, with lung cancer accounting for 20% of cancer-related deaths annually. Programs such as the Spanish Thoracic Tumour Registry (TTR) and the global I-O Optimise initiative have been developed to observe patients in clinical practice with the aim of improving outcomes. This analysis examined treatment patterns and survival in patients with stage III NSCLC from the TTR. These patients represent a heterogenous group with complex treatment pathways. Methods: The TTR is an ongoing, observational, prospective, and retrospective cohort multicentre study (NCT02941458) that follows patients with thoracic cancer in Spain. Adults aged ≥18 years with stage IIIA/IIIB NSCLC enrolled in the TTR between 01 Jan 2010 and 31 Oct 2019 were included in this analysis.Initial treatment received was described by cancer stage and histology (squamous and non-squamous NSCLC). Kaplan-Meier estimates of progression-free survival (PFS) and overall survival (OS) were calculated over a 5-year period. Results: A total of 1,838 patients were included in the cohort, including 1,082 with stage IIIA (58.9%) and 756 with stage IIIB (41.1%). Median follow-up was 18.3 months. The median age of patients was 66 years, and most had non-squamous NSCLC (54.0%), were male (81.2%), and were active or former smokers (93.4%). Overall, 26.3% of patients received surgical resection (37.0% for stage IIIA and 11.1% for stage IIIB). The most frequent initial treatment received was conc urrent chemoradiotherapy for stage IIIA (30.2%) and stage IIIB (37.0%) patients. Median OS was lower in patients with stage IIIB than stage IIIA (28 vs. 37 months) disease and was lower for patients with squamous than non-squamous histology (19 vs.26 months). Median PFS and OS varied when patients were stratified by initial treatment. Conclusions: This TTR analysis describes the clinical reality surrounding the initial management and survival outcomes for stage III NSCLC in Spain and presents survival outcomes comparable with other real-world evidence. It provides insights into the diverse approaches used before the availability of immunotherapies and targeted treatments in the non-metastatic NSCLC setting.
dc.language.iso	eng
dc.relation.ispartof	Translational Lung Cancer Research, 2023, vol. 12, num. 10, p. 2113-2128
dc.source	Provencio Pulla, Mariano Carcereny, Enric López Castro, Rafael Calvo, Virginia Rodríguez Abreu, Delvys Cobo, Manuel Ortega, Ana Laura Bernabé, Reyes Guirado, Maria Massuti Sureda, Bartomeu Barco, Edel Bosch Barrera, Joaquim Camps Herrero, Carlos Carroll, Robert Rault, Caroline Chaib, Carlos Penrod, John Vo, Lien Ralphs, Eleanor Daumont, Melinda 2023 Real-world treatment patterns and survival outcomes for patients with stage III non-small cell lung cancer in Spain : a nationwide cohort study Translational Lung Cancer Research 12 10 2113 2128
dc.subject	Càncer Pacients
dc.subject	Pulmons Malalties
dc.title	Real-world treatment patterns and survival outcomes for patients with stage III non-small cell lung cancer in Spain : a nationwide cohort study
dc.type	journal article
dc.date.updated	2023-11-06T15:07:16Z
dc.identifier.doi	10.21037/tlcr-23-176
dc.identifier.idgrec	161680
dc.rights.accessRights	open access