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Metabolomic and lipidomic approaches for fact-based nutrition assessment in infants and lactating mothers

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Metabolomic and lipidomic approaches for fact-based nutrition assessment in infants and lactating mothers

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dc.contributor.advisor	Kuligowski, Julia
dc.contributor.advisor	Ten Doménech, Isabel
dc.contributor.author	Ramos García, Victoria
dc.contributor.other	Departament de Química Analítica	es_ES
dc.date.accessioned	2023-11-15T10:23:43Z
dc.date.available	2023-11-16T05:45:06Z
dc.date.issued	2023	es_ES
dc.date.submitted	13-11-2023	es_ES
dc.identifier.uri	https://hdl.handle.net/10550/91157
dc.description.abstract	This PhD thesis addressed the different metabolomic and lipidomic approaches for nutrition assessment in infants and their lactating mothers in the frame of prematurity. Preterm infants’ (PI) early nutrition is one of the most important factors in improving their clinical outcomes. In this sense, breastfeeding is the gold standard of child nutrition due to human milk (HM) nutrients and bioactive components which contribute to the optimal growth and development of the infant. When not enough own mother’s milk (OMM) is available, the administration of pasteurized donor human milk (DHM) is considered a suitable alternative for preterm infants. To ensure the safety of DHM, milk banks routinely employ Holder pasteurization (HoP) in order to destroy or inactivate potential pathogenic bacteria and viruses present. However, HM composition can be affected by this process. In addition, this work has focused on the potential effect of maternal diet on HM composition. Likewise, diet is one of the key factors involved in the conformation of the intestinal microbiome, affecting microbial diversity, as well as the abundance of specific microbes. Different sample preprocessing methods have been applied to urine, faeces and HM samples before analysis using targeted, semi-targeted and untargeted metabolomic and lipidomic analytical methods. Liquid chromatography-tandem mass spectrometry (LC-MS/MS), gas chromatography coupled to MS (GC-MS), and attenuated total reflectance - Fourier transform infrared spectroscopy (ATR-FTIR) methods have been developed for the analysis of nutrition and microbiome activity biomarkers, as well as to study HM composition and the effect of HoP on it. The different developed analytical methodologies have been successfully applied to different sets of biological samples, demonstrating their applicability in the clinical field.	es_ES
dc.format.extent	476 p.	es_ES
dc.language.iso	en	es_ES
dc.subject	Metabolomics	es_ES
dc.subject	Lipidomics	es_ES
dc.subject	Analytical chemistry	es_ES
dc.subject	Preterm infants	es_ES
dc.subject	Lactating mothers	es_ES
dc.subject	Nutrition	es_ES
dc.subject	Microbiota	es_ES
dc.title	Metabolomic and lipidomic approaches for fact-based nutrition assessment in infants and lactating mothers	es_ES
dc.type	doctoral thesis	es_ES
dc.subject.unesco	UNESCO::QUÍMICA	es_ES
dc.embargo.terms	0 days	es_ES
dc.rights.accessRights	open access	es_ES