NAGIOS: RODERIC FUNCIONANDO

N-Acetylcysteine normalizes brain oxidative stress and neuroinflammation observed after protracted ethanol abstinence: a preclinical study in long-term ethanol-experienced male rats

Repositori DSpace/Manakin

Valencià Castellano

Inici
Investigació
e-prints
23 - Química
Visualitza element

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

N-Acetylcysteine normalizes brain oxidative stress and neuroinflammation observed after protracted ethanol abstinence: a preclinical study in long-term ethanol-experienced male rats

Mostra el registre parcial de l'element

dc.contributor.author	Fernández Rodríguez, Sandra
dc.contributor.author	Cano Cebrián, María José
dc.contributor.author	Esposito-Zapero, Claudia
dc.contributor.author	Rius Pérez, Sergio
dc.contributor.author	Guerri Sirera, Consuelo
dc.contributor.author	Zornoza Sabina, Teodoro
dc.contributor.author	Polache Vengut, Ana
dc.date.accessioned	2023-11-15T14:56:30Z
dc.date.available	2023-11-15T14:56:30Z
dc.date.issued	2023
dc.identifier.uri	https://hdl.handle.net/10550/91189
dc.description.abstract	Rationale Using a preclinical model based on the Alcohol Deprivation Effect (ADE), we have reported that N-Acetylcysteine (NAC) can prevent the relapse-like drinking behaviour in long-term ethanol-experienced male rats. Objectives To investigate if chronic ethanol intake and protracted abstinence affect several glutamate transporters and whether NAC, administered during the withdrawal period, could restore the ethanol-induced brain potential dysfunctions. Furthermore, the antioxidant and anti-inflammatory effects of NAC during abstinence in rats under the ADE paradigm were also explored. Methods The expression of GLT1, GLAST and xCT in nucleus accumbens (Nacc) and dorsal striatum (DS) of male Wistar was analysed after water and chronic ethanol intake. We used the model based on the ADE within another cohort of male Wistar rats. During the fourth abstinence period, rats were treated for 9 days with vehicle or NAC (60, 100 mg/kg; s.c.). The effects of NAC treatment on (i) glutamate transporters expression in the Nacc and DS, (ii) the oxidative status in the hippocampus (Hip) and amygdala (AMG) and (iii) some neuroinflammatory markers in prefrontal cortex (PFC) were tested. Results NAC chronic administration during protracted abstinence restored oxidative stress markers (GSSG and GGSH/GSH) in the Hip. Furthermore, NAC was able to normalize some neuroinflammation markers in PFC without normalizing the observed downregulation of GLT1 and GLAST in Nacc. Conclusions NAC restores brain oxidative stress and neuroinflammation that we previously observed after protracted ethanol abstinence in long-term ethanol-experienced male rats. This NAC effect could be a plausible mechanism for its anti-relapse effect. Also, brain oxidative stress and neuroinflammation could represent and identify plausible targets for searching new anti-relapse pharmacotherapies.
dc.language.iso	eng
dc.relation.ispartof	Psychopharmacology, 2023, vol. 240, p. 725-738
dc.source	Fernández Rodríguez, Sandra, Cano Cebrián, María José, Esposito-Zapero, Claudia, Rius Pérez, Sergio, Guerri Sirera, Consuelo, Zornoza Sabina, Teodoro, Polache Vengut, Ana (2023). N-Acetylcysteine normalizes brain oxidative stress and neuroinflammation observed after protracted ethanol abstinence: a preclinical study in long-term ethanol-experienced male rats Psychopharmacology 240 725 738. https://doi.org/10.1007/s00213-023-06311-z
dc.subject	genètica molecular
dc.subject	química
dc.title	N-Acetylcysteine normalizes brain oxidative stress and neuroinflammation observed after protracted ethanol abstinence: a preclinical study in long-term ethanol-experienced male rats
dc.type	journal article
dc.date.updated	2023-11-15T14:56:30Z
dc.identifier.doi	10.1007/s00213-023-06311-z
dc.identifier.idgrec	156693
dc.rights.accessRights	open access