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Local acamprosate modulates dopamine release in the rat nucleus accumbens through NMDA receptors: an in vivo microdialysis study

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Local acamprosate modulates dopamine release in the rat nucleus accumbens through NMDA receptors: an in vivo microdialysis study

dc.contributor.author	Cano Cebrián, María José
dc.contributor.author	Zornoza Sabina, Teodoro
dc.contributor.author	Guerri Sirera, Consuelo
dc.contributor.author	Polache Vengut, Ana
dc.contributor.author	Granero Maciá, Luis
dc.date.accessioned	2023-11-17T10:56:18Z
dc.date.available	2023-11-17T10:56:18Z
dc.date.issued	2003
dc.identifier.uri	https://hdl.handle.net/10550/91237
dc.description.abstract	The effects of acamprosate on the in vivo dopamine extracellular levels in the nucleus accumbens and the involvement of N-methyl-D-aspartate (NMDA) receptors in these effects were investigated. Microdialysis in freely moving rats was used to assess dopamine levels before and during simultaneous perfusion of acamprosate and/or different agonists or antagonists of NMDA receptors. Perfusion with acamprosate at concentrations of 0.5 and 5 mM provoked a concentration-dependent increase in extracellular dopamine in nucleus accumbens. The lowest concentration of acamprosate assayed (0.05 mM) had no effect on dopamine levels. Infusion of NMDA (25 and 500 µM) and the glutamate uptake blocker, L-trans-pyrrolidine-2,4-dicarboxilic acid (PDC) (0.5 mM) into the NAc caused a significant increase in DA, whereas acamprosate (0.05 mM) co-infusion with these compounds blocked or attenuated the NMDA and PDC-induced increases in DA levels. Co-infusion of the selective antagonist of NMDA receptors, DL-2-amino-5-phosphonopentanoic acid (AP5) (400 µM) with acamprosate (0.5 mM), did not reduce the increase of DA levels induced by acamprosate. These results demonstrate that acamprosate is able to modulate DA extracellular levels in NAc via NMDA receptors and suggest that acamprosate acts as an antagonist of NMDA receptors.
dc.language.iso	eng
dc.relation.ispartof	Naunyn-Schmiedebergs Archives of Pharmacology, 2003, vol. 367, p. 119-125
dc.source	Cano Cebrián, María José, Zornoza Sabina, Teodoro, Guerri Sirera, Consuelo, Polache Vengut, Ana, Granero Maciá, Luis (2003). Local acamprosate modulates dopamine release in the rat nucleus accumbens through NMDA receptors: an in vivo microdialysis study Naunyn-Schmiedebergs. Archives of Pharmacology 367 119 125. https://doi.org/10.1007/s00210-002-0674-3
dc.subject	tecnologia farmacèutica
dc.subject	farmàcia
dc.subject	farmacologia
dc.title	Local acamprosate modulates dopamine release in the rat nucleus accumbens through NMDA receptors: an in vivo microdialysis study
dc.type	journal article
dc.date.updated	2023-11-17T10:56:19Z
dc.identifier.doi	10.1007/s00210-002-0674-3
dc.identifier.idgrec	004316
dc.rights.accessRights	open access