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Acamprosate blocks the increase in dopamine extracellular levels in nucleus accumbens evoked by chemical stimulation of the ventral hippocampus

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Acamprosate blocks the increase in dopamine extracellular levels in nucleus accumbens evoked by chemical stimulation of the ventral hippocampus

dc.contributor.author	Cano Cebrián, María José
dc.contributor.author	Zornoza Sabina, Teodoro
dc.contributor.author	Guerri Sirera, Consuelo
dc.contributor.author	Polache Vengut, Ana
dc.contributor.author	Granero Maciá, Luis
dc.date.accessioned	2023-11-17T11:12:39Z
dc.date.available	2023-11-17T11:12:39Z
dc.date.issued	2003
dc.identifier.uri	https://hdl.handle.net/10550/91238
dc.description.abstract	Recently, we have shown that acamprosate is able to modulate extracellular dopamine (DA) levels in the nucleus accumbens (NAc) and may act as an antagonist of N-methyl-D-aspartate (NMDA) receptors. Neurochemical studies show that chemical stimulation (using NMDA) of the ventral subiculum (vSub) of the hippocampus produces robust and sustained increases in extracellular DA levels in the NAc, an effect mediated through ionotropic glutamate (iGlu) receptors. The present study examines whether acamprosate locally infused in the NAc of rats could block or attenuate the increase in NAc extracellular DA elicited by chemical stimulation (with 5 mM NMDA) of the ventral subiculum of the hippocampus. The stimulation of the vSub during perfusion of artificial cerebrospinal fluid in NAc induced a significant and persistent increase in NAc DA levels. Reverse dialysis of 0.05 mM acamprosate in NAc blocked the increase in DA evoked by the chemical stimulation of the vSub. These data support the possibility that the antagonism at the NMDA receptors in NAc can explain, at least in part, the mechanism of action of this drug.
dc.language.iso	eng
dc.relation.ispartof	Naunyn-Schmiedebergs Archives of Pharmacology, 2003, vol. 368, p. 324-327
dc.source	Cano Cebrián, María José Zornoza Sabina, Teodoro Guerri Sirera, Consuelo Polache Vengut, Ana Granero Maciá, Luis 2003 Acamprosate blocks the increase in dopamine extracellular levels in nucleus accumbens evoked by chemical stimulation of the ventral hippocampus Naunyn-Schmiedebergs Archives of Pharmacology 368 324 327. https://doi.org/10.1007/s00210-003-0795-3
dc.subject	tecnologia farmacèutica
dc.subject	farmàcia
dc.subject	farmacologia
dc.title	Acamprosate blocks the increase in dopamine extracellular levels in nucleus accumbens evoked by chemical stimulation of the ventral hippocampus
dc.type	journal article
dc.date.updated	2023-11-17T11:12:39Z
dc.identifier.doi	10.1007/s00210-003-0795-3
dc.identifier.idgrec	004315
dc.rights.accessRights	open access