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Pharmacology of acamprosate: an overview

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Pharmacology of acamprosate: an overview

dc.contributor.author	Zornoza Sabina, Teodoro
dc.contributor.author	Cano Cebrián, María José
dc.contributor.author	Polache Vengut, Ana
dc.contributor.author	Granero Maciá, Luis
dc.date.accessioned	2023-11-17T11:19:52Z
dc.date.available	2023-11-17T11:19:52Z
dc.date.issued	2003
dc.identifier.uri	https://hdl.handle.net/10550/91239
dc.description.abstract	In the last years important advances have been made in the development of drugs for the treatment of alcohol addiction. Acamprosate (calcium bis-acetylhomotaurine) is one of the better established drugs in this field on the European market. This review focuses first on the pharmacokinetics of acamprosate. The published data and the recent advances in our knowledge on the mechanisms involved in the intestinal absorption and elimination of this drug are summarized. The importance of pharmacokinetics for the proper clinical use of acamprosate is highlighted. The anti-relapse as well as the well-known effects of acamprosate on ethanol intake are discussed. The recent experiments in animal models of conditioned withdrawal are reviewed. These experiments, explored for the first time the anticraving effect of the drug. Finally, the proposed hypotheses on the neuropharmacological mechanism of action of acamprosate are discussed. The discussion deals with the relative importance of various hypotheses as well as with the recent experiments that support them. It is pointed out that further research is necessary in order to clearly understand the mode of action of acamprosate as well as the neurobiological mechanisms involved in alcohol dependence.
dc.language.iso	eng
dc.relation.ispartof	CNS Drug Reviews, 2003, vol. 9, num. 4, p. 359-374
dc.source	Zornoza Sabina, Teodoro, Cano Cebrián, María José, Polache Vengut, Ana, Granero Maciá, Luis (2003). Pharmacology of acamprosate: an overview CNS Drug Reviews 9 4 359 374. https://doi.org/10.1111/j.1527-3458.2003.tb00260.x
dc.subject	tecnologia farmacèutica
dc.subject	farmacologia
dc.subject	farmàcia
dc.title	Pharmacology of acamprosate: an overview
dc.type	journal article
dc.date.updated	2023-11-17T11:19:52Z
dc.identifier.doi	10.1111/j.1527-3458.2003.tb00260.x
dc.identifier.idgrec	004314
dc.rights.accessRights	open access