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Regional differences in mu-opioid receptor-dependent modulation of basal dopamine transmission in rat striatum

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Regional differences in mu-opioid receptor-dependent modulation of basal dopamine transmission in rat striatum

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dc.contributor.author	Campos Jurado, Yolanda María
dc.contributor.author	Martí Prats, Lucía
dc.contributor.author	Zornoza Sabina, Teodoro
dc.contributor.author	Polache Vengut, Ana
dc.contributor.author	Granero Maciá, Luis
dc.contributor.author	Cano Cebrián, María José
dc.date.accessioned	2023-11-17T15:03:27Z
dc.date.available	2023-11-17T15:03:27Z
dc.date.issued	2017
dc.identifier.uri	https://hdl.handle.net/10550/91243
dc.description.abstract	The nigrostriatal dopamine system is implicated in the regulation of reward and motor activity. Dopamine (DA) release in dorsal striatum (DS) is controlled by the firing rate of DA neurons in substantia nigra pars compacta. However, influences at terminal level, such as those involving activation of mu opioid receptors (MORs), can play a key role in determining DA levels in striatum. Nonetheless, published data also suggest that the effect of opioid drugs on DA levels may differ depending on the DS subregion analysed. In this study, in vivo microdialysis in rats was used to explore this regional dependence. Changes in basal DA levels induced by local retrodialysis application of DAMGO (selective MORs agonist) in three different subregions of DS along the rostro-caudal axis were studied. Our results indicate that whereas administration of 10μM DAMGO into the rostral and caudal DS significantly reduced DA levels, in medial DS an increase in DA levels was observed. These data reveal a regional-dependent MOR modulation of DA release in DS, similar to that described in the ventral striatum. Our findings may lead to a better understanding of the nigrostriatal DA system regulation.
dc.language.iso	eng
dc.relation.ispartof	Neuroscience Letters, 2017, vol. 638, p. 102-108
dc.source	Campos Jurado, Yolan, María Martí Prats, Lucía, Zornoza Sabina, Teodoro, Polache Vengut, Ana, Granero Maciá, Lui,s Cano Cebrián, María José (2017). Regional differences in mu-opioid. Letters 638 102 108. https://doi.org/10.1016/j.neulet.2016.12.024
dc.subject	dopamina
dc.subject	farmacologia
dc.subject	drogues
dc.title	Regional differences in mu-opioid receptor-dependent modulation of basal dopamine transmission in rat striatum
dc.type	journal article
dc.date.updated	2023-11-17T15:03:27Z
dc.identifier.doi	10.1016/j.neulet.2016.12.024
dc.identifier.idgrec	114855
dc.rights.accessRights	open access