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Estimation of personalized minimal Purkinje systems from human electro-anatomical maps

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Estimation of personalized minimal Purkinje systems from human electro-anatomical maps

dc.contributor.author	Barber Miralles, Fernando
dc.contributor.author	Langfield, P.
dc.contributor.author	Lozano Ibáñez, Miguel
dc.contributor.author	García Fernández, Ignacio
dc.contributor.author	Duchateau, J.
dc.contributor.author	Meleze, H.
dc.contributor.author	Haissaguerre, M.
dc.contributor.author	Vigmond, E.
dc.contributor.author	Sebastián Aguilar, Rafael
dc.date.accessioned	2023-11-22T12:53:21Z
dc.date.available	2023-11-22T12:53:21Z
dc.date.issued	2021
dc.identifier.uri	https://hdl.handle.net/10550/91327
dc.description.abstract	The Purkinje system is a heart structure responsible for transmitting electrical impulses through the ventricles in a fast and coordinated way to trigger mechanical contraction. Estimating a patient-specific compatible Purkinje Network from an electro-anatomical map is a challenging task, that could help to improve models for electrophysiology simulations or provide aid in therapy planning, such as radiofrequency ablation. In this study, we present a methodology to inversely estimate a Purkinje network from a patient's electro-anatomical map. First, we carry out a simulation study to assess the accuracy of the method for different synthetic Purkinje network morphologies and myocardial junction densities. Second, we estimate the Purkinje network from a set of 28 electro-anatomical maps from patients, obtaining an optimal conduction velocity in the Purkinje network of 1.95 ± 0.25 m/s, together with the location of their Purkinje-myocardial junctions, and Purkinje network structure. Our results showed an average local activation time error of 6.8±2.2 ms in the endocardium. Finally, using the personalized Purkinje network, we obtained correlations higher than 0.85 between simulated and clinical 12-lead ECGs.
dc.language.iso	eng
dc.relation.ispartof	IEEE Transactions on Medical Imaging, 2021, vol. 40, num. 8, p. 2182-2194
dc.source	F. Barber et al., "Estimation of Personalized Minimal Purkinje Systems From Human Electro-Anatomical Maps," in IEEE Transactions on Medical Imaging, vol. 40, no. 8, pp. 2182-2194, Aug. 2021, doi: 10.1109/TMI.2021.3073499.
dc.subject	informàtica
dc.subject	medicina informàtica
dc.title	Estimation of personalized minimal Purkinje systems from human electro-anatomical maps
dc.type	journal article
dc.date.updated	2023-11-22T12:53:22Z
dc.identifier.doi	10.1109/TMI.2021.3073499
dc.identifier.idgrec	148694
dc.rights.accessRights	open access