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The Golgi complex of dopaminergic enteric neurons is fragmented in a hemiparkinsonian rat model

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The Golgi complex of dopaminergic enteric neurons is fragmented in a hemiparkinsonian rat model

dc.contributor.author	Cara-Esteban, Mireia
dc.contributor.author	Marín Muela, María Pilar
dc.contributor.author	Martínez-Alonso, Emma
dc.contributor.author	Martínez Bellver, Sergio
dc.contributor.author	Teruel Martí, Vicent
dc.contributor.author	Martínez-Menárguez, José-Ángel
dc.contributor.author	Tomás-Caballero, Mónica
dc.date.accessioned	2023-11-24T13:49:48Z
dc.date.available	2023-11-24T13:49:48Z
dc.date.issued	2023
dc.identifier.uri	https://hdl.handle.net/10550/91413
dc.description.abstract	Since gastrointestinal disorders are early consequences of Parkinson's disease (PD), this disease is clearly not restricted to the central nervous system (CNS), but also significantly affects the enteric nervous system (ENS). Large aggregates of the protein α-synuclein forming Lewy bodies, the prototypical cytopathological marker of this disease, have been observed in enteric nervous plexuses. However, their value in early prognosis is controversial. The Golgi complex (GC) of nigral neurons appears fragmented in Parkinson's disease, a characteristic common in most neurodegenerative diseases. In addition, the distribution and levels of regulatory proteins such as Rabs and SNAREs are altered, suggesting that PD is a membrane traffic-related pathology. Whether the GC of enteric dopaminergic neurons is affected by the disease has not yet been analyzed. In the present study, dopaminergic neurons in colon nervous plexuses behave as nigral neurons in a hemiparkinsonian rat model based on the injection of the toxin 6-OHDA. Their GCs are fragmented, and some regulatory proteins' distribution and expression levels are altered. The putative mechanisms of the transmission of the neurotoxin to the ENS are discussed. Our results support the possibility that GC structure and the level of some proteins, especially syntaxin 5, could be helpful as early indicators of the disease.
dc.language.iso	eng
dc.relation.ispartof	Microscopy Research and Technique, 2023
dc.source	Cara-Esteban, Mireia, Marín Muela, María Pilar,Martínez-Alonso, Emma, Martínez Bellver, Sergio, Teruel Martí, Vicent, Martínez-Menárguez, José-Ángel, Tomás-Caballero, Mónica (2023). The Golgi complex of dopaminergic enteric neurons is fragmented in a hemiparkinsonian rat model. Microscopy Research and Technique. https://doi.org/10.1002/jemt.24442
dc.subject	neurologia
dc.subject	investigació
dc.title	The Golgi complex of dopaminergic enteric neurons is fragmented in a hemiparkinsonian rat model
dc.type	journal article
dc.date.updated	2023-11-24T13:49:49Z
dc.identifier.doi	10.1002/jemt.24442
dc.identifier.idgrec	161612
dc.rights.accessRights	open access