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Morphological Analysis of New Cytopathological Hallmarks in Dopaminergic Enteric Neurons of Parkinson's disease

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Morphological Analysis of New Cytopathological Hallmarks in Dopaminergic Enteric Neurons of Parkinson's disease

dc.contributor.author	Cara-Esteban, Mireia
dc.contributor.author	Marín Muela, María Pilar
dc.contributor.author	Martínez Bellver, Sergio
dc.contributor.author	Teruel Martí, Vicent
dc.contributor.author	Martínez-Alonso, Emma
dc.contributor.author	Martínez-Menárguez, José-Ángel
dc.contributor.author	Tomás-Caballero, Mónica
dc.date.accessioned	2023-11-24T14:14:46Z
dc.date.available	2023-11-24T14:14:46Z
dc.date.issued	2021
dc.identifier.uri	https://hdl.handle.net/10550/91416
dc.description.abstract	Parkinson's disease (PD) is the second most frequent neurodegenerative disease in the world. The main histological hallmark is the accumulation of misfolded α-synuclein, conforming Lewy bodies and Lewy neurites and loss of dopaminergic neurons in substantia nigra pars compacta (SNpc). There have been described alterations in Golgi apparatus (GA) organization, which is the central organelle of intracellular traffic, in PD and other neurodegenerative diseases. Our previous studies, using cellular models of PD, demonstrate that GA fragmentation is an early event previous to α-synuclein aggregation and cytoskeletal alterations (1) and recently we have found that the SNARE protein syntaxin 5 forms extracellular aggregates resembling the amyloid plaques characteristic of Alzheimer's disease in dopaminergic neurons in human samples of SNpc of PD patients (2). Moreover, there is also evidence of this pathology not only in the central nervous system, but also in the enteric nervous system (ENS) neurons, which has drawn attention in the last years. Recently, gastrointestinal symptomatology, previous to motor symptoms in PD, has been the reason to think that lesions in ENS could develop earlier in the course of the disease, therefore, the study of ENS could help to understand this pathology. The purpose of this study was to analyze, using morphological techniques, the structure of GA, and cytoskeleton organization of enteric dopaminergic neurons of an experimental hemiparkinsonian rat model induced by 6-OHDA. The results obtained showed alterations in GA cytoarchitecture, cytoskeleton microtubules organization and Sintaxin-5 (SNARE). These findings support the ENS as object of study of possible specific biomarkers for early diagnosis of PD.
dc.language.iso	eng
dc.relation.ispartof	Journal of Experimental Neuroscience, 2021, vol. 5, num. Supplement 1,2, p. S11
dc.source	Cara-Esteban, Mireia, Marín Muela, María Pilar, Martínez Bellver, Sergio, Teruel Martí, Vicent, Martínez-Alonso, Emma, Martínez-Menárguez, José-Ángel, Tomás-Caballero, Mónica (2021). Morphological Analysis of New Cytopathological Hallmarks in Dopaminergic Enteric Neurons of Parkinson's disease. Journal of Experimental Neuroscience 5 Supplement 1,2 S11. https://doi.org/10.17756/jnen.2021-suppl1
dc.subject	neurologia
dc.subject	malalties
dc.subject	health oigong
dc.subject	parkinson’s disease
dc.subject	anxiety
dc.subject	depression
dc.title	Morphological Analysis of New Cytopathological Hallmarks in Dopaminergic Enteric Neurons of Parkinson's disease
dc.type	journal article
dc.date.updated	2023-11-24T14:14:47Z
dc.identifier.doi	10.17756/jnen.2021-suppl1
dc.identifier.idgrec	162187
dc.rights.accessRights	open access