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Fragmentation of the Golgi complex of dopaminergic neurons in human substantia nigra: new citopathological findings in Parkinson's disease

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Fragmentation of the Golgi complex of dopaminergic neurons in human substantia nigra: new citopathological findings in Parkinson's disease

dc.contributor.author	Tomás-Caballero, Mónica
dc.contributor.author	Martínez-Alonso, Emma
dc.contributor.author	Martínez-Martínez, Narcisa
dc.contributor.author	Cara-Esteban, Mireia
dc.contributor.author	Martínez-Menárguez, José-Ángel
dc.date.accessioned	2023-11-24T14:22:13Z
dc.date.available	2023-11-24T14:22:13Z
dc.date.issued	2021
dc.identifier.uri	https://hdl.handle.net/10550/91418
dc.description.abstract	Fragmentation of the Golgi ribbon is a common feature of Parkinson's disease and other neurodegenerative diseases. This alteration could be the consequence of the anterograde and retrograde transport imbalance, α-synuclein aggregates, and/or cytoskeleton alterations. Most information on this process has been obtained from cellular and animal experimental models, and as such, there is little information available on human tissue. If the information on human tissue was available, it may help to understand the cytopathological mechanisms of this disease. In the present study, we analyzed the morphological characteristics of the Golgi complex of dopaminergic neurons in human samples of substantia nigra of control and Parkinson's disease patients. We measured the expression levels of putative molecules involved in Golgi fragmentation, including α- synuclein, tubulin, and Golgi-associated regulatory and structural proteins. We show that, as a consequence of the disease, the Golgi complex is fragmented into small stacks without vesiculation. We found that only a limited number of regulatory proteins are altered. Rab1, a small GTPase regulating endoplasmic reticulum-to-Golgi transport, is the most dramatically affected, being highly overexpressed in the surviving neurons. We found that the SNARE protein syntaxin 5 forms extracellular aggregates resembling the amyloid plaques characteristic of Alzheimer's disease. These findings may help to understand the cytopathology of Parkinson's disease.
dc.language.iso	eng
dc.relation.ispartof	Histology and Histopathology, 2021, vol. 36, p. 47-60
dc.source	Tomás-Caballero, Mónica, Martínez-Alonso, Emma, Martínez-Martínez, Narcisa, Cara-Esteban, Mireia Martínez-Menárguez, José-Ángel (2021). Fragmentation of the Golgi complex of dopaminergic neurons in human substantia nigra: new citopathological findings, in Parkinson's disease Histology and Histopathology, 36, 47 60. https://doi.org/10.14670/hh-18-270
dc.subject	neurologia
dc.subject	malalties
dc.subject	golgi complex
dc.subject	parkinson's disease
dc.subject	dopaminergic neurons
dc.subject	substantia nigra
dc.subject	membrane traffic
dc.title	Fragmentation of the Golgi complex of dopaminergic neurons in human substantia nigra: new citopathological findings in Parkinson's disease
dc.type	journal article
dc.date.updated	2023-11-24T14:22:14Z
dc.identifier.doi	10.14670/hh-18-270
dc.identifier.idgrec	140841
dc.rights.accessRights	open access