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Focus on the Small GTPase Rab1 : A Key Player in the Pathogenesis of Parkinson's Disease

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Focus on the Small GTPase Rab1 : A Key Player in the Pathogenesis of Parkinson's Disease

dc.contributor.author	Martínez-Menárguez, José-Ángel
dc.contributor.author	Martínez-Alonso, Emma
dc.contributor.author	Cara-Esteban, Mireia
dc.contributor.author	Tomás-Caballero, Mónica
dc.date.accessioned	2023-11-24T14:24:30Z
dc.date.available	2023-11-24T14:24:30Z
dc.date.issued	2021
dc.identifier.uri	https://hdl.handle.net/10550/91419
dc.description.abstract	Parkinson's disease (PD) is the second most frequent neurodegenerative disease. It is characterized by the loss of dopaminergic neurons in the substantia nigra and the formation of large aggregates in the survival neurons called Lewy bodies, which mainly contain α-synuclein (α-syn). The cause of cell death is not known but could be due to mitochondrial dysfunction, protein homeostasis failure, and alterations in the secretory/endolysosomal/autophagic pathways. Survival nigral neurons overexpress the small GTPase Rab1. This protein is considered a housekeeping Rab that is necessary to support the secretory pathway, the maintenance of the Golgi complex structure, and the regulation of macroautophagy from yeast to humans. It is also involved in signaling, carcinogenesis, and infection for some pathogens. It has been shown that it is directly linked to the pathogenesis of PD and other neurodegenerative diseases. It has a protective effect against α-σψν toxicity and has recently been shown to be a substrate of LRRK2, which is the most common cause of familial PD and the risk of sporadic disease. In this review, we analyze the key aspects of Rab1 function in dopamine neurons and its implications in PD neurodegeneration/restauration. The results of the current and former research support the notion that this GTPase is a good candidate for therapeutic strategies.
dc.language.iso	eng
dc.relation.ispartof	International Journal Of Molecular Sciences, 2021, vol. 22, num. 21, p. 12087
dc.source	Martínez-Menárguez, J.Á.; Martínez-Alonso, E.; Cara-Esteban, M.; Tomás, M. Focus on the Small GTPase Rab1: A Key Player in the Pathogenesis of Parkinson’s Disease. Int. J. Mol. Sci. 2021, 22, 12087. https://doi.org/10.3390/ijms222112087
dc.subject	neurologia
dc.subject	malalties
dc.subject	autophagy
dc.subject	GTPases
dc.subject	parkinson’s disease
dc.subject	secretory pathway
dc.subject	golgi fragmentation
dc.title	Focus on the Small GTPase Rab1 : A Key Player in the Pathogenesis of Parkinson's Disease
dc.type	journal article
dc.date.updated	2023-11-24T14:24:31Z
dc.identifier.doi	10.3390/ijms222112087
dc.identifier.idgrec	149015
dc.rights.accessRights	open access