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Golgi Fragmentation in Neurodegenerative Diseases: Is There a Common Cause?

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Golgi Fragmentation in Neurodegenerative Diseases: Is There a Common Cause?

dc.contributor.author	Martínez-Menárguez, José-Ángel
dc.contributor.author	Tomás-Caballero, Mónica
dc.contributor.author	Martínez-Martínez, Narcisa
dc.contributor.author	Martínez-Alonso, Emma
dc.date.accessioned	2023-11-24T14:48:53Z
dc.date.available	2023-11-24T14:48:53Z
dc.date.issued	2019
dc.identifier.uri	https://hdl.handle.net/10550/91422
dc.description.abstract	In most mammalian cells, the Golgi complex forms a continuous ribbon. In neurodegenerative diseases, the Golgi ribbon of a specific group of neurons is typically broken into isolated elements, a very early event which happens before clinical and other pathological symptoms become evident. It is not known whether this phenomenon is caused by mechanisms associated with cell death or if, conversely, it triggers apoptosis. When the phenomenon was studied in diseases such as Parkinson's and Alzheimer's or amyotrophic lateral sclerosis, it was attributed to a variety of causes, including the presence of cytoplasmatic protein aggregates, malfunctioning of intracellular tra c and/or alterations in the cytoskeleton. In the present review, we summarize the current findings related to these and other neurodegenerative diseases and try to search for clues on putative common causes.
dc.language.iso	eng
dc.relation.ispartof	Cells, 2019, vol. 19
dc.source	Martínez-Menárguez, J.Á.; Tomás, M.; Martínez-Martínez, N.; Martínez-Alonso, E. Golgi Fragmentation in Neurodegenerative Diseases: Is There a Common Cause? Cells 2019, 8, 748. https://doi.org/10.3390/cells8070748
dc.subject	neurologia
dc.subject	malalties
dc.subject	golgi complex
dc.subject	neurodegenerative diseases
dc.subject	intracellular transport
dc.subject	cytoskeleton
dc.subject	protein aggregates
dc.title	Golgi Fragmentation in Neurodegenerative Diseases: Is There a Common Cause?
dc.type	journal article
dc.date.updated	2023-11-24T14:48:54Z
dc.identifier.doi	10.3390/cells8070748
dc.identifier.idgrec	134668
dc.rights.accessRights	open access