NAGIOS: RODERIC FUNCIONANDO

Micellar liquid chromatography as a sustainable tool to quantify three statins in oral solid dosage forms

Repositori DSpace/Manakin

Valencià Castellano

Inici
Investigació
e-prints
23 - Química
Visualitza element

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

Micellar liquid chromatography as a sustainable tool to quantify three statins in oral solid dosage forms

Mostra el registre parcial de l'element

dc.contributor.author	García López, Lidia
dc.contributor.author	Peris Vicente, Juan
dc.contributor.author	Carda Broch, Samuel
dc.date.accessioned	2023-11-27T14:18:48Z
dc.date.available	2023-11-27T14:18:48Z
dc.date.issued	2023
dc.identifier.uri	https://hdl.handle.net/10550/91458
dc.description.abstract	A method based on micellar liquid chromatography has been developed to determine rosuvastatin, lovastatin and simvastatin in oral solid dosage forms. Samples were solved in mobile phase up to the target concentration, filtered and directly injected. The three statins were resolved in 30 min, using an aqueous solution of 0.10 M sodium dodecyl sulphate - 7.0% 1-butanol, buffered at pH 3 with 0.01 M phosphate salt as mobile phase, running under isocratic mode at 1 mL/min through a C18 column. Detection was at 240 nm. The effect of sodium dodecyl sulfate on elution strength was more important than that of the organic solvent. The procedure was successfully validated by the guidelines of the International Council for Harmonization in terms of: specificity, linearity (r2 > 0.990), calibration range (1.5 - 15 mg/L for rosuvastatin, 0.5-10 mg/L for lovastatin and simvastatin), limit of detection (0.4, 0.2 and 0.15 mg/L for rosuvastatin, lovastatin and simvastatin, respectively), trueness (98.8-101.7%), precision (<2.7%), carry-over effect, robustness, and stability. Values were inside the acceptance criteria of the Methods, Method Verification and Validation, Food and Drug Administration-Office of Regulatory Affairs, thus ensuring the reliability of the results. The main feature was the low proportion of organic solvent used, thus making the procedure sustainable and green. Besides, it was easy-to-conduct and with high sample-throughput, and then useful for routine analysis in pharmaceutical quality control. Finally, it was applied to commercial pharmaceutical preparations.
dc.language.iso	eng
dc.relation.ispartof	Journal of Chromatography A, 2023, vol. 1968, p. 464000
dc.source	García López, Lidia, Peris Vicente, Juan, Carda Broch, Samuel (202). Micellar liquid chromatography as a sustainable tool to quantify three statins in oral solid dosage forms. Journal of Chromatography A, 1968, 464000. https://doi.org/10.1016/j.chroma.2023.464000
dc.subject	química analítica
dc.subject	lovastatin
dc.subject	pharmaceutical
dc.subject	rosuvastatin
dc.subject	simvastatin
dc.subject	validation
dc.title	Micellar liquid chromatography as a sustainable tool to quantify three statins in oral solid dosage forms
dc.type	journal article
dc.date.updated	2023-11-27T14:18:48Z
dc.identifier.doi	10.1016/j.chroma.2023.464000
dc.identifier.idgrec	157689
dc.rights.accessRights	open access