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Salivary and gingival crevicular fluid histatin in periodontal health and disease

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Salivary and gingival crevicular fluid histatin in periodontal health and disease

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dc.contributor.author Bhadbhade, Smruti J. es
dc.contributor.author Acharya, Anirudh B. es
dc.contributor.author Thakur, Srinath L es
dc.date.accessioned 2014-05-22T09:38:38Z
dc.date.available 2014-05-22T09:38:38Z
dc.date.issued 2013 es
dc.identifier.citation Bhadbhade, Smruti J. ; Acharya, Anirudh B. ; Thakur, Srinath L. Salivary and gingival crevicular fluid histatin in periodontal health and disease. En: Journal of Clinical and Experimental Dentistry, 2013, Vol. 5, No. 4: 174-178 es
dc.identifier.uri http://hdl.handle.net/10550/35338
dc.description.abstract Objectives: Histatin, with its anti bacterial, anti protease, and wound closure stimulating property might influence the pathogenesis of periodontal disease. This study assessed the presence of histatin in gingival crevicular fluid (GCF); the levels of salivary and GCF histatin in periodontal disease. Material and methods: It was a cross sectional study that included systemically healthy forty five subjects (22 males and 23 females) between the age group of 20 to 45 years. Based on Gingival Index (Loe and Silness ,1963) and Russell's Periodontal Index they were grouped as 15 healthy (Group 1), 15 gingivitis (Group 2), and 15 periodontitis (Group 3) subjects. Whole pooled unstimulated saliva was collected by asking the patient to spit in a sterile container and GCF samples were collected using a micropipette from all the subjects. Histatin levels were assessed using Enzyme Linked Immunosorbent Assay (ELISA). The intergroup comparison was done by ANOVA and Mann Whitney U Test was done for pair wise comparison. Results: The results of this study show that histatin is present in saliva and gingival crevicular fluid. When the salivary histatin levels were compared it was found that the levels of histatin increase from health to periodontitis but the levels of histatin in the gingival crevicular fluid and saliva had no correlation with severity of periodontal disease as there was no statistically significant difference between the three groups. Conclusions: It can be concluded that histatin cannot be used as a potential marker of periodontal disease. en_US
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Salivary and gingival crevicular fluid histatin in periodontal health and disease es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.type.hasVersion VoR es_ES

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