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Analysis of methylation and mRNA expression status of FADD and FAS genes in patients with oral squamous cell carcinoma

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Analysis of methylation and mRNA expression status of FADD and FAS genes in patients with oral squamous cell carcinoma

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dc.contributor.author Saberi, Eshaghali es
dc.contributor.author Kordi-Tamandani, Dor-Mohammad es
dc.contributor.author Jamali, Sara es
dc.contributor.author Rigi-Ladez, Mohammad-Ayoub es
dc.contributor.author Augend, Arsalan es
dc.date.accessioned 2015-01-08T12:36:15Z
dc.date.available 2015-01-08T12:36:15Z
dc.date.issued 2014 es
dc.identifier.citation Saberi, Eshaghali ; Kordi-Tamandani, Dor-Mohammad ; Jamali, Sara ; Rigi-Ladez, Mohammad-Ayoub ; Augend, Arsalan. Analysis of methylation and mRNA expression status of FADD and FAS genes in patients with oral squamous cell carcinoma. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2014, Vol. 19, No. 6: 562-568 es
dc.identifier.uri http://hdl.handle.net/10550/41168
dc.description.abstract Background: Apoptosis is an important mechanism that is responsible for the physiological deletion of harmful, damaged, or unwanted cells. Changed expression of apoptosis-related genes may lead to abnormal cell proliferation and finally to tumorigenesis. Our aims were to analyze the promoter methylation and gene expression profiles of FADD and FAS genes in risk of OSCC. Material and Methods: we analyze the promoter methylation status of FADD and FAS genes using Methylation - Specific PCR (MSP) in 86 OSCC tissues were kept in paraffin and 68 normal oral tissues applied as control. Also, FADD and FAS genes expression were analyzed in 19 cases and 20 normal specimens by Real-Time Reverse- Transcripts PCR. Results: Aberrant promoter methylation of FADD and FAS genes were detected in 12.79 % (11 of 86) and 60.46 % (52 of 86) of the OSCC cases, respectively, with a significant difference between cases and healthy controls for both FADD and FAS genes ( P <0.001). The gene expression analysis showed statistically significant difference between cases and healthy controls for both FADD ( p <0.02) and FAS ( p <0.007) genes. Conclusions: To the best our knowledge, the data of this study are the first report regarding, the effect of promoter hypermethylation of the FADD and FAS genes in development of OSCC. To confirm the data, it is recommended doing further study in large sample sizes in various genetic populations. en_US
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Analysis of methylation and mRNA expression status of FADD and FAS genes in patients with oral squamous cell carcinoma es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.type.hasVersion VoR es_ES
dc.identifier.url http://www.medicinaoral.com/pubmed/medoralv19_i6_p562.pdf es

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