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Membrane insertion and topology of the translocon-associated protein (TRAP) gamma subunit

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Membrane insertion and topology of the translocon-associated protein (TRAP) gamma subunit

dc.contributor.author	Bañó Polo, Manuel
dc.contributor.author	Martínez Garay, Carlos Andrés
dc.contributor.author	Grau, Brayan
dc.contributor.author	Martínez Gil, Luis
dc.contributor.author	Mingarro Muñoz, Ismael
dc.date.accessioned	2017-03-28T14:41:46Z
dc.date.available	2018-01-27T05:45:05Z
dc.date.issued	2017
dc.identifier.citation	Bañó Polo, Manuel Martínez Garay, Carlos Andrés Grau, Brayan Martínez Gil, Luis Mingarro Muñoz, Ismael 2017 Membrane insertion and topology of the translocon-associated protein (TRAP) gamma subunit Biochimica et Biophysica Acta-Biomembranes 1859 5 903 909
dc.identifier.uri	http://hdl.handle.net/10550/58014
dc.description.abstract	Translocon-associated protein (TRAP) complex is intimately associated with the ER translocon for the insertion or translocation of newly synthesised proteins in eukaryotic cells. The TRAP complex is comprised of three single-spanning and one multiple-spanning subunits. We have investigated the membrane insertion and topology of the multiple-spanning TRAP-γ subunit by glycosylation mapping and green fluorescent protein fusions both in vitro and in cell cultures. Results demonstrate that TRAP-γ has four transmembrane (TM) segments, an Nt/Ct cytosolic orientation and that the less hydrophobic TM segment inserts efficiently into the membrane only in the cellular context of full-length protein.
dc.language.iso	eng
dc.relation.ispartof	Biochimica et Biophysica Acta-Biomembranes, 2017, vol. 1859, num. 5, p. 903-909
dc.subject	Proteïnes de membrana
dc.subject	Membranes (Biologia)
dc.title	Membrane insertion and topology of the translocon-associated protein (TRAP) gamma subunit
dc.type	journal article	es_ES
dc.date.updated	2017-03-28T14:41:47Z
dc.identifier.doi	10.1016/j.bbamem.2017.01.027
dc.identifier.idgrec	115652
dc.embargo.terms	1 year
dc.rights.accessRights	open access	es_ES