Objectives: To evaluate the sealing capability of Cavit TM G with or without Clearfil TM S3 Bond and Prime & Bond NT placed in the pulp chamber. Study Design: Forty single rooted premolars, extracted for orthodontic and periodontal reasons, with intact coronal surface and mature apices, were standardized to a length of 15 mm. The teeth were instrumented, filled with a gutta-percha master cone and divided into three groups to obturate the pulp chambers: Cavit TM G; Clearfil TM S3 Bond plus Cavit TM G and Prime & Bond® NT plus Cavit TM G. A glucose leakage model was used for evaluating the coronal microleakage. The Mann-Whitney test was used to evaluate the differences in the means of the glucose leakage. Results: An increase in glucose penetration was observed during the first week in groups Cavit TM G and Cavit TM G+PBNT. The glucose penetration values of all groups were similar at 30 and 45 days, and there were no significant differences among them in both time periods (p=0.736 and p=0.581, respectively). Conclusions: The adhesive systems did not improve the capability of Cavit TM G to seal the pulp chamber over time © Medicina Oral S. L.