The purpose of this study was to evaluate the deflection forces of 0.016-inch Nitinol and stainless steel orthodontic wires, in association to different self-ligating brackets. Specimens were mounted in a clinical simulation model and evaluated in a Universal Testing Machine (INSTRON 3342), using a 10N load cell and ISO 15,841, as a protocol. Eight of these models were prepared, each one for the bonding of each set of self-ligating accessories to be tested: Damon Q, Damon Clear (Ormco), In-Ovation R, In-Ovation C (GAC), BioQuick, QuickClear (Forestadent), SmartClip and Clarity SL (3M). Data were subjected to One-way ANOVA, followed by Tukey tests (P<0.05). Elastic deflection results showed that the deactivation forces increased with increase in wire deflection in the different brackets evaluated. For the different combinations, Clarity SL generated the greatest force and Damon Clear presented the lowest force when compared to the other brackets in all alloys and deflections. BioQuick and QuicKlear were those with the most similar behavior with each other. Strength values increased with gradual increase in wire deflection in all evaluated brackets. Clarity SL generated the greatest and Damon Clear the lowest force when compared to the other brackets in all alloys and deflections tested.