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Enantioselective synthesis of 2‑amino-1,1-diarylalkanes bearing a carbocyclic ring substituted indole through asymmetric catalytic reaction of hydroxyindoles with nitroalkenes

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Enantioselective synthesis of 2‑amino-1,1-diarylalkanes bearing a carbocyclic ring substituted indole through asymmetric catalytic reaction of hydroxyindoles with nitroalkenes

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dc.contributor.author	Vila Descals, Carlos
dc.contributor.author	Rostoll Berenguer, Jaume
dc.contributor.author	Sánchez-García, Rubén
dc.contributor.author	Blay Llinares, Gonzalo
dc.contributor.author	Fernández Picot, Isabel
dc.contributor.author	Muñoz, M. Carmen
dc.contributor.author	Pedro, José Ramón
dc.date.accessioned	2020-04-01T10:26:28Z
dc.date.available	2020-04-01T10:26:28Z
dc.date.issued	2018
dc.identifier.citation	Vila Descals, Carlos Rostoll-Berenguer, Jaume Sánchez-García, Rubén Blay Llinares, Gonzalo Fernández Picot, Isabel Muñoz, M. Carmen Pedro, José Ramón 2018 Enantioselective synthesis of 2‑amino-1,1-diarylalkanes bearing a carbocyclic ring substituted indole through asymmetric catalytic reaction of hydroxyindoles with nitroalkenes Journal of Organic Chemistry 83 6397 6407
dc.identifier.uri	https://hdl.handle.net/10550/73731
dc.description.abstract	An asymmetric catalytic reaction of hydroxyindoles with nitroalkenes leading to the Friedel−Crafts alkylation in the carbocyclic ring of indole is presented. The method is based on the activating/directing effects of the hydroxy group situated in the carbocyclic ring of the indole providing nitroalkylated indoles functionalizated at the C-4, C-5, and C-7 positions with high yield, regio-, and enantioselectivity. The optically enriched nitroalkanes were transformed efficiently in optically enriched 2-amino-1,1-diarylalkanes bearing a carbocyclic ring substituted indole.
dc.language.iso	eng
dc.relation.ispartof	Journal of Organic Chemistry, 2018, vol. 83, p. 6397-6407
dc.subject	Química orgànica
dc.subject	Catàlisi
dc.subject	Reaccions químiques
dc.title	Enantioselective synthesis of 2‑amino-1,1-diarylalkanes bearing a carbocyclic ring substituted indole through asymmetric catalytic reaction of hydroxyindoles with nitroalkenes
dc.type	journal article	es_ES
dc.date.updated	2020-04-01T10:26:29Z
dc.identifier.doi	10.1021/acs.joc.8b00612
dc.identifier.idgrec	126270
dc.rights.accessRights	open access	es_ES