NAGIOS: RODERIC FUNCIONANDO

Fibrinogen Gamma Chain Promotes Aggregation of Vesicular Stomatitis Virus in Saliva

Repositori DSpace/Manakin

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

Fibrinogen Gamma Chain Promotes Aggregation of Vesicular Stomatitis Virus in Saliva

Mostra el registre parcial de l'element

dc.contributor.author Anschau, Valesca
dc.contributor.author Sanjuán Verdeguer, Rafael
dc.date.accessioned 2020-04-07T09:12:46Z
dc.date.available 2020-04-07T09:12:46Z
dc.date.issued 2020
dc.identifier.citation Anschau, Valesca Sanjuán Verdeguer, Rafael 2020 Fibrinogen Gamma Chain Promotes Aggregation of Vesicular Stomatitis Virus in Saliva Viruses 12 282 1 12
dc.identifier.uri https://hdl.handle.net/10550/73815
dc.description.abstract The spread of viruses among cells and hosts often involves multi-virion structures. For instance, virions can form aggregates that allow for the co-delivery of multiple genome copies to the same cell from a single infectious unit. Previously, we showed that vesicular stomatitis virus (VSV), an enveloped, negative-strand RNA virus, undergoes strong aggregation in the presence of saliva from certain individuals. However, the molecular components responsible for such aggregation remain unknown. Here we show that saliva-driven aggregation is protein dependent, and we use comparative proteomics to analyze the protein content of strongly versus poorly aggregating saliva. Quantitative analysis of over 300 proteins led to the identification of 18 upregulated proteins in strongly aggregating saliva. One of these proteins, the fibrinogen gamma chain, was verified experimentally as a factor promoting VSV aggregation in a dose-dependent manner. This study hence identifies a protein responsible for saliva-driven VSV aggregation. Yet, the possible involvement of additional proteins or factors cannot be discarded.
dc.language.iso eng
dc.relation.ispartof Viruses, 2020, vol. 12, num. 282, p. 1-12
dc.subject Virologia
dc.subject Virus
dc.title Fibrinogen Gamma Chain Promotes Aggregation of Vesicular Stomatitis Virus in Saliva
dc.type journal article es_ES
dc.date.updated 2020-04-07T09:12:47Z
dc.identifier.doi 10.3390/v12030282
dc.identifier.idgrec 137621
dc.rights.accessRights open access es_ES

Visualització       (1.684Mb)

Aquest element apareix en la col·lecció o col·leccions següent(s)

Mostra el registre parcial de l'element

Cerca a RODERIC

Cerca avançada

Visualitza

Estadístiques