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Enantioselective synthesis of chiral oxazolines from unactivated ketones and isocyanoacetate esters by synergistic silver/organocatalysis

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Enantioselective synthesis of chiral oxazolines from unactivated ketones and isocyanoacetate esters by synergistic silver/organocatalysis

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dc.contributor.author	Martínez-Pardo, Pablo
dc.contributor.author	Blay Llinares, Gonzalo
dc.contributor.author	Muñoz, M. Carmen
dc.contributor.author	Pedro, José Ramón
dc.contributor.author	Sanz Marco, Amparo
dc.contributor.author	Vila Descals, Carlos
dc.date.accessioned	2020-09-28T14:16:05Z
dc.date.available	2020-09-28T14:16:05Z
dc.date.issued	2018
dc.identifier.citation	Martínez-Pardo, Pablo Blay Llinares, Gonzalo Muñoz, M. Carmen Pedro, José Ramón Sanz Marco, Amparo Vila Descals, Carlos 2018 Enantioselective synthesis of chiral oxazolines from unactivated ketones and isocyanoacetate esters by synergistic silver/organocatalysis Chemical Communications 54 2862 2865
dc.identifier.uri	https://hdl.handle.net/10550/75670
dc.description.abstract	A multicatalytic approach that combines a bifunctional Brønsted base-squaramide organocatalyst and Ag+ as Lewis acid has been applied in the reaction of unactivated ketones with tert-butyl isocyanoacetate to give chiral oxazolines bearing a quaternary stereocenter. The formal [3+2] cycloaddition provided high yields of the corresponding cis-oxazolines with good diastereoselectivity and excellent enantioselectivity, being applied to aryl-alkyl and alkyl-alkyl ketones.
dc.language.iso	eng
dc.relation.ispartof	Chemical Communications, 2018, vol. 54, p. 2862-2865
dc.subject	Catàlisi
dc.subject	Química orgànica
dc.title	Enantioselective synthesis of chiral oxazolines from unactivated ketones and isocyanoacetate esters by synergistic silver/organocatalysis
dc.type	journal article	es_ES
dc.date.updated	2020-09-28T14:16:05Z
dc.identifier.doi	10.1039/C8CC00856F
dc.identifier.idgrec	124130
dc.rights.accessRights	open access	es_ES