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Viral Bcl2s' transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis

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Viral Bcl2s' transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis

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García Murria, María Jesús; Duart, Gerard; Grau, Brayan; Diaz-Beneitez, Elisabet; Rodríguez, Dolores; Mingarro Muñoz, Ismael; Martínez Gil, Luis

Aquest document és un/a article, creat/da en: 2020

Viral control of programmed cell death relies in part on the expression of viral analogs of the B-cell lymphoma 2 (Bcl2) protein known as viral Bcl2s (vBcl2s). vBcl2s control apoptosis by interacting with host pro- and anti-apoptotic members of the Bcl2 family. Here, we show that the carboxyl-terminal hydrophobic region of herpesviral and poxviral vBcl2s can operate as transmembrane domains (TMDs) and participate in their homo-oligomerization. Additionally, we show that the viral TMDs mediate interactions with cellular pro- and anti-apoptotic Bcl2 TMDs within the membrane. Furthermore, these intra-membrane interactions among viral and cellular proteins are necessary to control cell death upon an apoptotic stimulus. Therefore, their inhibition represents a new potential therapy against viral infections, which are characterized by short- and long-term deregulation of programmed cell death.

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