NAGIOS: RODERIC FUNCIONANDO

Viral Bcl2s' transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis

Repositori DSpace/Manakin

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

Viral Bcl2s' transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis

dc.contributor.author	García Murria, María Jesús
dc.contributor.author	Duart, Gerard
dc.contributor.author	Grau, Brayan
dc.contributor.author	Diaz-Beneitez, Elisabet
dc.contributor.author	Rodríguez, Dolores
dc.contributor.author	Mingarro Muñoz, Ismael
dc.contributor.author	Martínez Gil, Luis
dc.date.accessioned	2021-04-27T12:45:29Z
dc.date.available	2021-04-27T12:45:29Z
dc.date.issued	2020
dc.identifier.citation	García Murria, María Jesús Duart, Gerard Grau, Brayan Diaz-Beneitez, Elisabet Rodríguez, Dolores Mingarro Muñoz, Ismael Martínez Gil, Luis 2020 Viral Bcl2s' transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis Nature Communications 11 6056
dc.identifier.uri	https://hdl.handle.net/10550/78942
dc.description.abstract	Viral control of programmed cell death relies in part on the expression of viral analogs of the B-cell lymphoma 2 (Bcl2) protein known as viral Bcl2s (vBcl2s). vBcl2s control apoptosis by interacting with host pro- and anti-apoptotic members of the Bcl2 family. Here, we show that the carboxyl-terminal hydrophobic region of herpesviral and poxviral vBcl2s can operate as transmembrane domains (TMDs) and participate in their homo-oligomerization. Additionally, we show that the viral TMDs mediate interactions with cellular pro- and anti-apoptotic Bcl2 TMDs within the membrane. Furthermore, these intra-membrane interactions among viral and cellular proteins are necessary to control cell death upon an apoptotic stimulus. Therefore, their inhibition represents a new potential therapy against viral infections, which are characterized by short- and long-term deregulation of programmed cell death.
dc.language.iso	eng
dc.relation.ispartof	Nature Communications, 2020, vol. 11, num. 6056
dc.subject	Proteïnes
dc.subject	Virus
dc.title	Viral Bcl2s' transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis
dc.type	journal article	es_ES
dc.date.updated	2021-04-27T12:45:29Z
dc.identifier.doi	10.1038/s41467-020-19881-9
dc.identifier.idgrec	141636
dc.rights.accessRights	open access	es_ES