NAGIOS: RODERIC FUNCIONANDO

MYC Induces a Hybrid Energetics Program Early in Cell Reprogramming

Repositori DSpace/Manakin

Valencià Castellano

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

MYC Induces a Hybrid Energetics Program Early in Cell Reprogramming

Mostra el registre complet de l'element

Visualització (3.190Mb)

Prieto Martínez, Javier; Seo, Arnold Y.; León Rodríguez, Marian; Santacatterina, Fulvio; Torresano, Laura; Palomino-Schätzlein, Martina; Giménez, Karen; Vallet-Sánchez, Azahara; Ponsoda i Martí, Xavier; Pineda Lucena, Antonio; Cuezva, José M.; Lippincott-Schwartz, Jennifer; Torres Ibáñez, José Manuel

Aquest document és un/a article, creat/da en: 2018

Cell reprogramming is thought to be associated with a full metabolic switch from an oxidative- to a glycolytic-based metabolism. However, neither the dynamics nor the factors controlling this metabolic switch are fully understood. By using cellular, biochemical, protein array, metabolomic, and respirometry analyses, we found that c-MYC establishes a robust bivalent energetics program early in cell reprogramming. Cells prone to undergo reprogramming exhibit high mitochondrial membrane potential and display a hybrid metabolism. We conclude that MYC proteins orchestrate a rewiring of somatic cell metabolism early in cell reprogramming, whereby somatic cells acquire the phenotypic plasticity necessary for their transition to pluripotency in response to either intrinsic or external cues.

Veure al catàleg Trobes