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MYC Induces a Hybrid Energetics Program Early in Cell Reprogramming

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MYC Induces a Hybrid Energetics Program Early in Cell Reprogramming

dc.contributor.author	Prieto Martínez, Javier
dc.contributor.author	Seo, Arnold Y.
dc.contributor.author	León Rodríguez, Marian
dc.contributor.author	Santacatterina, Fulvio
dc.contributor.author	Torresano, Laura
dc.contributor.author	Palomino-Schätzlein, Martina
dc.contributor.author	Giménez, Karen
dc.contributor.author	Vallet-Sánchez, Azahara
dc.contributor.author	Ponsoda i Martí, Xavier
dc.contributor.author	Pineda Lucena, Antonio
dc.contributor.author	Cuezva, José M.
dc.contributor.author	Lippincott-Schwartz, Jennifer
dc.contributor.author	Torres Ibáñez, José Manuel
dc.date.accessioned	2022-10-21T13:22:10Z
dc.date.available	2022-10-21T13:22:10Z
dc.date.issued	2018
dc.identifier.citation	Prieto Martínez, Javier Seo, Arnold Y. León Rodríguez, Marian Santacatterina, Fulvio Torresano, Laura Palomino-Schätzlein, Martina Giménez, Karen Vallet-Sánchez, Azahara Ponsoda i Martí, Xavier Pineda Lucena, Antonio Cuezva, José M. Lippincott-Schwartz, Jennifer Torres Ibáñez, José Manuel 2018 MYC Induces a Hybrid Energetics Program Early in Cell Reprogramming Stem Cell Reports 11 6 1479 1492
dc.identifier.uri	https://hdl.handle.net/10550/84236
dc.description.abstract	Cell reprogramming is thought to be associated with a full metabolic switch from an oxidative- to a glycolytic-based metabolism. However, neither the dynamics nor the factors controlling this metabolic switch are fully understood. By using cellular, biochemical, protein array, metabolomic, and respirometry analyses, we found that c-MYC establishes a robust bivalent energetics program early in cell reprogramming. Cells prone to undergo reprogramming exhibit high mitochondrial membrane potential and display a hybrid metabolism. We conclude that MYC proteins orchestrate a rewiring of somatic cell metabolism early in cell reprogramming, whereby somatic cells acquire the phenotypic plasticity necessary for their transition to pluripotency in response to either intrinsic or external cues.
dc.language.iso	eng
dc.relation.ispartof	Stem Cell Reports, 2018, vol. 11, num. 6, p. 1479-1492
dc.subject	Cèl·lules
dc.subject	Mitocondris
dc.title	MYC Induces a Hybrid Energetics Program Early in Cell Reprogramming
dc.type	journal article	es_ES
dc.date.updated	2022-10-21T13:22:11Z
dc.identifier.doi	10.1016/j.stemcr.2018.10.018
dc.identifier.idgrec	128985
dc.rights.accessRights	open access	es_ES