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A robust reprogramming strategy for generating hepatocyte-like cells usable in pharmaco-toxicological studies.

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A robust reprogramming strategy for generating hepatocyte-like cells usable in pharmaco-toxicological studies.

dc.contributor.author	Garcia Llorens, Guillem
dc.contributor.author	Martínez Sena, Teresa
dc.contributor.author	Pareja Ibars, Eugenia
dc.contributor.author	Tolosa Pardo, Laia
dc.contributor.author	Castell, José V.
dc.contributor.author	Bort Martí, Roque
dc.date.accessioned	2023-05-30T17:10:57Z
dc.date.available	2023-05-30T17:10:57Z
dc.date.issued	2023
dc.identifier.citation	Garcia Llorens, Guillem Martínez Sena, Teresa Pareja Ibars, Eugenia Tolosa Pardo, Laia Castell, José V. Bort Martí, Roque 2023 A robust reprogramming strategy for generating hepatocyte-like cells usable in pharmaco-toxicological studies. Stem Cell Research & Therapy 14 1 94
dc.identifier.uri	https://hdl.handle.net/10550/87131
dc.description.abstract	High-throughput pharmaco-toxicological testing frequently relies on the use of established liver-derived cell lines, such as HepG2 cells. However, these cells often display limited hepatic phenotype and features of neoplastic transformation that may bias the interpretation of the results. Alternate models based on primary cultures or differentiated pluripotent stem cells are costly to handle and difficult to implement in high-throughput screening platforms. Thus, cells without malignant traits, optimal differentiation pattern, producible in large and homogeneous amounts and with patient-specific phenotypes would be desirable.
dc.language.iso	eng
dc.relation.ispartof	Stem Cell Research & Therapy, 2023, vol. 14, num. 1, p. 94
dc.subject	Química farmacèutica
dc.title	A robust reprogramming strategy for generating hepatocyte-like cells usable in pharmaco-toxicological studies.
dc.type	journal article
dc.date.updated	2023-05-30T17:10:58Z
dc.identifier.doi	10.1186/s13287-023-03311-w
dc.identifier.idgrec	159552
dc.rights.accessRights	open access