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Identification of small molecules capable of enhancing viral membrane fusion

Repositori DSpace/Manakin

Valencià Castellano

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

Identification of small molecules capable of enhancing viral membrane fusion

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García Murria, María Jesús; Gadea Salom, Laura; Moreno, Sandra; Rius Salvador, Marina; Zaragoza, Óscar; Brun, Alejandro; Mingarro Muñoz, Ismael; Martínez Gil, Luis

Aquest document és un/a article, creat/da en: 2023

Several approaches have been developed to analyze the entry of highly pathogenic viruses. In this study, we report the implementation of a Bimolecular Multicellular Complementation (BiMuC) assay to safely and efficiently monitor SARS-CoV-2 S-mediated membrane fusion without the need for microscopy-based equipment. Using BiMuC, we screened a library of approved drugs and identified compounds that enhance S protein-mediated cell-cell membrane fusion. Among them, ethynylestradiol promotes the growth of SARS-CoV-2 and Influenza A virus in vitro. Our findings demonstrate the potential of BiMuC for identifying small molecules that modulate the life cycle of enveloped viruses, including SARS-CoV-2.

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