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Identification of small molecules capable of enhancing viral membrane fusion

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Identification of small molecules capable of enhancing viral membrane fusion

dc.contributor.author	García Murria, María Jesús
dc.contributor.author	Gadea Salom, Laura
dc.contributor.author	Moreno, Sandra
dc.contributor.author	Rius Salvador, Marina
dc.contributor.author	Zaragoza, Óscar
dc.contributor.author	Brun, Alejandro
dc.contributor.author	Mingarro Muñoz, Ismael
dc.contributor.author	Martínez Gil, Luis
dc.date.accessioned	2023-09-13T13:27:46Z
dc.date.available	2023-09-13T13:27:46Z
dc.date.issued	2023
dc.identifier.citation	García Murria, María Jesús Gadea Salom, Laura Moreno, Sandra Rius Salvador, Marina Zaragoza, Óscar Brun, Alejandro Mingarro Muñoz, Ismael Martínez Gil, Luis 2023 Identification of small molecules capable of enhancing viral membrane fusion Virology Journal 20 99
dc.identifier.uri	https://hdl.handle.net/10550/89228
dc.description.abstract	Several approaches have been developed to analyze the entry of highly pathogenic viruses. In this study, we report the implementation of a Bimolecular Multicellular Complementation (BiMuC) assay to safely and efficiently monitor SARS-CoV-2 S-mediated membrane fusion without the need for microscopy-based equipment. Using BiMuC, we screened a library of approved drugs and identified compounds that enhance S protein-mediated cell-cell membrane fusion. Among them, ethynylestradiol promotes the growth of SARS-CoV-2 and Influenza A virus in vitro. Our findings demonstrate the potential of BiMuC for identifying small molecules that modulate the life cycle of enveloped viruses, including SARS-CoV-2.
dc.language.iso	eng
dc.relation.ispartof	Virology Journal, 2023, vol. 20, num. 99
dc.subject	Virus
dc.title	Identification of small molecules capable of enhancing viral membrane fusion
dc.type	journal article
dc.date.updated	2023-09-13T13:27:47Z
dc.identifier.doi	10.1186/s12985-023-02068-1
dc.identifier.idgrec	161165
dc.rights.accessRights	open access