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Hierarchical mesoporous NanoMUV-2 for the selective delivery of macromolecular drugs
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Hierarchical mesoporous NanoMUV-2 for the selective delivery of macromolecular drugs
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| Abánades Lázaro, Isabel; Vicent-Morales, María; Mínguez Espallargas, Guillermo; Giménez-Marqués, Mónica | |||
| Aquest document és un/a article, creat/da en: 2023 | |||
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| Although Metal-organic frameworks (MOFs) have received attention as drug delivery systems, their application in the delivery of macromolecules is limited by their pore size and opening. Herein, we present the synthesis of nanostructured MUV-2, a hierarchical mesoporous iron-based MOF that can store high payloads of the macromolecular drug paclitaxel (ca. 23% w/w), increasing its selectivity towards HeLa cancer cells over HEK non-cancerous cells. Moreover, this NanoMUV-2 permits full degradation under simulated physiological conditions while maintaining biocompatibility, and is amenable to specific surface modifications that increase its cell permeation, efficient cytosol delivery and cancer-targeting effect, further intensifying the cancer selectivity of paclitaxel. | |||
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Abánades Lázaro, Isabel Vicent-Morales, María Mínguez Espallargas, Guillermo Giménez-Marqués, Mónica 2023 Hierarchical mesoporous NanoMUV-2 for the selective delivery of macromolecular drugs Journal Of Materials Chemistry B 11 9179 9184 |
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