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Hierarchical mesoporous NanoMUV-2 for the selective delivery of macromolecular drugs

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Hierarchical mesoporous NanoMUV-2 for the selective delivery of macromolecular drugs

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dc.contributor.author	Abánades Lázaro, Isabel
dc.contributor.author	Vicent-Morales, María
dc.contributor.author	Mínguez Espallargas, Guillermo
dc.contributor.author	Giménez-Marqués, Mónica
dc.date.accessioned	2023-11-13T11:25:20Z
dc.date.available	2023-11-13T11:25:20Z
dc.date.issued	2023
dc.identifier.uri	https://hdl.handle.net/10550/91060
dc.description.abstract	Although Metal-organic frameworks (MOFs) have received attention as drug delivery systems, their application in the delivery of macromolecules is limited by their pore size and opening. Herein, we present the synthesis of nanostructured MUV-2, a hierarchical mesoporous iron-based MOF that can store high payloads of the macromolecular drug paclitaxel (ca. 23% w/w), increasing its selectivity towards HeLa cancer cells over HEK non-cancerous cells. Moreover, this NanoMUV-2 permits full degradation under simulated physiological conditions while maintaining biocompatibility, and is amenable to specific surface modifications that increase its cell permeation, efficient cytosol delivery and cancer-targeting effect, further intensifying the cancer selectivity of paclitaxel.
dc.language.iso	eng
dc.relation.ispartof	Journal Of Materials Chemistry B, 2023, vol. 11, p. 9179-9184
dc.source	Abánades Lázaro, Isabel Vicent-Morales, María Mínguez Espallargas, Guillermo Giménez-Marqués, Mónica 2023 Hierarchical mesoporous NanoMUV-2 for the selective delivery of macromolecular drugs Journal Of Materials Chemistry B 11 9179 9184
dc.subject	Química
dc.subject	Materials
dc.title	Hierarchical mesoporous NanoMUV-2 for the selective delivery of macromolecular drugs
dc.type	journal article
dc.date.updated	2023-11-13T11:25:21Z
dc.identifier.doi	/10.1039/d3tb01819a
dc.identifier.idgrec	161669
dc.rights.accessRights	open access