In this work we show the most significant features of our research which has been accomplished with the collaboration of the Research and Scientific Politic Department of the University of València. It has been elaborated following a case study methodology, and it analyses the practice of six secondary school teachers who have been able to wake up their student's interest by using and innovative and contextualized methodology that provokes a significant learning. Instruments for data recompilation have been: in-depth interview, non-intervened observation and the analysis of the multimedia documents produced during their lessons. From the analysis of these data we have reached to the following conclusions among others: firstly, independently of the socio-cultural context and even using different methodologies, these teachers are obtaining good results due to their personal implication in the development of students-based activities; and, secondly, teachers' vocation and motivation are the basis for a good teaching professionalization.